Facile methodology of nanoemulsion preparation using oily polymer for the delivery of poorly soluble drugs
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چکیده
منابع مشابه
Nanoemulsion Formulations for Improved Oral Delivery of Poorly Soluble Drugs
The objective of this study was to develop nanoemulsion formulations for enhancement of oral bioavailability of paclitaxel, a model hydrophobic drug and P-glycoprotein substrate. The oil-in-water (o/w) nanoemulsions were made with pine nut oil as the internal oil phase, egg lecithin as the primary emulsifier, and water as the external phase. Stearylamine and deoxycholic acid were used to impart...
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a major hurdle in pharmaceutical formulation is water insolubility of most of drugs affecting their stability and bioavailability. if the drug is also insoluble in organic medium, it is difficult to deliver it in a sufficiently bioavailable form and hence it is a great challenge to formulation researchers to overcome such difficulty. although some approaches are available for enhancing the diss...
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Nanotechnology has been improving and has a variety of application fields. One of the major application areas of nanotechnology in pharmacy is nanoparticular drug delivery systems. Preparation of drug nanocrystals to improve the solubility of poorly water-soluble drugs for oral delivery is also one of the important applications. Nanocrystal dispersions comprise water, active drug substance and ...
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ژورنال
عنوان ژورنال: Drug Delivery and Translational Research
سال: 2019
ISSN: 2190-393X,2190-3948
DOI: 10.1007/s13346-019-00703-5